Oral Dysbiosis and Neuroinflammation: Implications for Alzheimer’s, Parkinson’s and Mood Disorders
Oral dysbiosis emerges as a modifiable contributor to neuroinflammation and brain health. Periodontal therapy, probiotics, prebiotics, synbiotics, and targeted inhibitors of bacterial virulence factors represent promising strategies to reduce systemic and neural inflammation. Longitudinal human studies and standardized microbiome methodologies are still needed to clarify causality and evaluate whether restoring oral microbial balance can modify the course of neuropsychiatric and neurodegenerative disorders.
Authors
- Joan S. Salas‐Leiva (ORCID: https://orcid.org/0000-0002-4141-140X)
- Mercedes Bermúdez (ORCID: https://orcid.org/0000-0002-6145-1134)
- Juan Antonio Arreguín-Cano (ORCID: https://orcid.org/0000-0003-1292-9880)
- Sandra Aidé Santana-Delgado
- Ana Delia Larrinúa-Pacheco
- Carlos Esteban Villegas-Mercado
- Uriel Soto-Barreras
- María Fernanda García-Vega
- Laura Carolina Zavala-Medina
Institutions
- Autonomous University of Chihuahua (MX)
- Centro de Investigación en Materiales Avanzados (MX)
Publication Details
- Journal
- Microorganisms
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3390/microorganisms14010143
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 42.00