Cumulative environmental exposures adversely impact social behaviour and are associated with dysregulation of genes and proteins involved in epigenetic, ribosomal, and immune regulation in male mice
Combined environmental stressors may drive male-specific behavioural and inflammatory changes relevant to NDDs. The identification of overlapping inflammatory signatures in brain and peripheral immune cells supports a role for shared immune mechanisms in brain-immune axis dysfunction. However, these pathway-level findings should be interpreted as preliminary hypotheses and warrant independent validation to confirm their mechanistic significance.
Authors
- Shrujna Patel (ORCID: https://orcid.org/0000-0003-4928-692X)
- Brooke A. Keating (ORCID: https://orcid.org/0009-0002-6444-2628)
- Peter Valtchev (ORCID: https://orcid.org/0000-0002-2622-5721)
- Brian Gloss (ORCID: https://orcid.org/0000-0001-7695-4394)
- Stela P. Petkova (ORCID: https://orcid.org/0000-0003-2700-184X)
- Mark Evan Graham (ORCID: https://orcid.org/0000-0002-7290-1217)
- Russell C. Dale (ORCID: https://orcid.org/0000-0002-2495-1826)
- Markus J. Hofer (ORCID: https://orcid.org/0000-0001-5111-3978)
- Nader Aryamanesh (ORCID: https://orcid.org/0000-0003-4666-9175)
- Pinki Dey (ORCID: https://orcid.org/0000-0001-8822-3599)
- Velda X. Han (ORCID: https://orcid.org/0000-0003-4633-4316)
- Xianzhong Lau (ORCID: https://orcid.org/0000-0001-7845-8933)
- Lee L. Marshall (ORCID: https://orcid.org/0000-0002-9884-4636)
- Ruwani Dissanayake
- Morgan C. Bucknor
- Anand Gururajan
Institutions
- The University of Sydney (AU)
- Children's Medical Research Institute (AU)
- National University of Singapore (SG)
- Children's Hospital at Westmead (AU)
- Khoo Teck Puat Hospital (SG)
- Westmead Institute (AU)
- Westmead Institute for Medical Research (AU)
- AGRF Ltd (AU)
Publication Details
- Journal
- Inflammation Research
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1007/s00011-025-02152-y
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children's Medical Research
- University of Sydney
- Medical Research Council
- National Health and Medical Research Council