A single-cell transcriptomic atlas of the periventricular proliferative zone in the late gestation fetal brain in the pigtail macaque
Single-cell populations from the third-trimester nonhuman primate fetal brain are highly similar to those in the human fetus. This late-gestation single-cell atlas of the periventricular proliferative zone provides a unique reference for progenitor, neuronal, glial, vascular, and immune cell states during a critical window of primate neurodevelopment, enabling mechanistic interrogation of how inflammatory, infectious, or hypoxic insults disrupt vulnerable neurogenic niches.
Authors
- Megana Shivakumar
- Kristen N. Noble (ORCID: https://orcid.org/0000-0003-3396-3172)
- Kristina M. Adams Waldorf (ORCID: https://orcid.org/0000-0002-6939-7224)
- Amanda Li (ORCID: https://orcid.org/0009-0008-4089-3655)
- Austyn Orvis
- Hazel Huang
- Beatrice Menz
- Jake Cornelius (ORCID: https://orcid.org/0009-0003-6381-9603)
- Sidney C. Sun (ORCID: https://orcid.org/0009-0003-7254-0401)
- Audrey E. Baldessari (ORCID: https://orcid.org/0000-0001-6392-3230)
- Solomon Wangari
- Hong Zhao (ORCID: https://orcid.org/0000-0003-1137-8028)
- Inah Golez (ORCID: https://orcid.org/0000-0002-5866-4120)
- Orlando Cervantes (ORCID: https://orcid.org/0000-0003-3187-9567)
- Miranda Li (ORCID: https://orcid.org/0000-0001-7541-3748)
- Stephen A. McCartney (ORCID: https://orcid.org/0000-0003-1102-6778)
- Gygeria Manuel (ORCID: https://orcid.org/0000-0002-9299-2574)
- Melissa R. Berg (ORCID: https://orcid.org/0000-0002-0053-9503)
- Mónica Selena Fonseca-Pérez
- Richard Li (ORCID: https://orcid.org/0000-0002-4666-6938)
- Briana M Del Rosario
- Britni Curtis (ORCID: https://orcid.org/0009-0002-5824-9856)
- Edmunda Li (ORCID: https://orcid.org/0009-0000-9426-3546)
- Andrew E Vo (ORCID: https://orcid.org/0009-0008-2367-6691)
- Pilar Flores Espinosa
- Andrea Olmos-Ortiz
- Raj P Kapur
- Akshaj Bharadwaj
- Jeff Munson
- Chris English
- Jin Dai
- Taeyun Kim
- Michelle Coleman
- Addy Cecilia Helguera-Repetto
Institutions
- Seattle Children's Hospital (US)
- Infectious Disease Research Institute (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Pacific Northwest University of Health Sciences (US)
- Instituto Nacional de Perinatología (MX)
- Allen Institute (US)
- University School (US)
- Saint Louis University (US)
- The University of Texas Medical Branch at Galveston (US)
- Case Western Reserve University (US)
- Morehouse School of Medicine (US)
- Columbia University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-08
- DOI
- https://doi.org/10.64898/2026.01.08.698393
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health