Antibody landscapes of arboviral exposure across China revealed by high-throughput seroprofiling from a peptide epitope library
Our findings reveal distinct regional and demographic patterns of arboviral antibody reactivity in China, reflecting differing histories of exposure and potentially informing region-specific surveillance strategies. The stable antibody levels across age groups, together with higher fold-change values in females, underscore the influence of biological and social factors on arboviral immunity. The ArboScan platform, and programmable peptide display platforms in general, offer a scalable approach to characterize population-level immunity and could enhance early detection and public health preparedness in arbovirus-endemic areas.
Authors
- F. Zhu
- Qianfeng Xia (ORCID: https://orcid.org/0000-0001-5521-5664)
- W. Liu
- Dai Z. Kuang
- Ying Luo (ORCID: https://orcid.org/0000-0002-7006-2122)
- Nan Zhang (ORCID: https://orcid.org/0000-0002-5759-3797)
- Wan Ni Chia
- Hua Pei
- Yuxuan Han
- Lin-Fa Wang
Institutions
- National University of Singapore (SG)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- Duke-NUS Medical School (SG)
- Hainan Medical University (CN)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Infectious Diseases of Poverty
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1186/s40249-025-01399-1
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Johns Hopkins University
- Duke-NUS Medical School
- National Natural Science Foundation of China
- Hainan Medical University
- Medical Research Council
- National Medical Research Council