Disseminated pediatric low-grade glioma and hydrocephalus: a multinational consortium analysis of incidence and mortality
This study represents the largest and most comprehensive cohort of patients with DPLGG to date. While histopathology and tumor location were associated with hydrocephalus in this cohort, the dissemination pattern was not directly associated with hydrocephalus incidence but rather the timing of hydrocephalus diagnosis. Hydrocephalus does not impact survival in patients with DPLGG; however, it is associated with worse functional outcomes.
Authors
- Khurram Minhas (ORCID: https://orcid.org/0000-0002-6210-4636)
- Joseline Haizel‐Cobbina (ORCID: https://orcid.org/0000-0003-0273-6639)
- Prabhumallikarjun Patil (ORCID: https://orcid.org/0000-0002-2855-1555)
- Anthony E. Bishay (ORCID: https://orcid.org/0000-0002-6057-3770)
- Michelle Ku
- Frank K.H. van Landeghem (ORCID: https://orcid.org/0000-0002-9404-7031)
- Adriana Fonseca (ORCID: https://orcid.org/0000-0002-6382-6833)
- Louise Ludlow (ORCID: https://orcid.org/0009-0000-0001-8946)
- Jordan R. Hansford (ORCID: https://orcid.org/0000-0001-7733-383X)
- Álvaro Lassaletta (ORCID: https://orcid.org/0000-0003-2881-1473)
- Ernest Nelson
- Amanda M. Luck
- Annette Weiser
- Richard Graham (ORCID: https://orcid.org/0000-0002-8566-5970)
- Yoshiko Nakano (ORCID: https://orcid.org/0000-0001-5394-8194)
- Robert Siddaway (ORCID: https://orcid.org/0000-0003-2013-9467)
- Hunter Caroline Davies
- Igor L. Fernandes
- Adrian Levine
- Filip Jadrijević Cvrlje
- Nicolette Jew
- Jean M. Mulcahy Levy (ORCID: https://orcid.org/0000-0002-3022-4246)
- Scott Raskin (ORCID: https://orcid.org/0000-0003-1160-9842)
- H. Toledano
- Richard Yuditskiy
- V LAROUCHE
- Roaya M Masoud
- Shawde Campbell
- Palak Patel (ORCID: https://orcid.org/0000-0003-4768-8124)
- Uri Y. Tabori
- Kai Yamasaki
- Cyril Li
- Beverly A. Wilson
- C. Hawkins
- Fumiyuki Yamasaki
- Alexander T Lyons
- Andrew Son
- A. Guerreiro Stücklin
- Lane Williamson
- Julie Bennett
- José E. Velázquez
- John-Paul Kilday
- Andrew T. Hale
- James T. Rutka
- Ashley S. Plant-Fox
- Fumiharu Ohka
- David D. Eisenstat
- MacLean P. Nasrallah
- Michael C. Dewan
- Panagiota Giannakouros
- Karina Black
- Craig Erker
- James M. Johnston
- Peter B. Dirks
- Alisa Talianski
- Sylvia Cheng
- Luis Blasco-Santana
- Chantel Cacciotti
- Tomonari Suzuki
- Adam J. Fleming
- Christopher Dunham
Institutions
- Western University (CA)
- Cincinnati Children's Hospital Medical Center (US)
- Dalhousie University (CA)
- Royal Children's Hospital (AU)
- Children's Hospital of Philadelphia (US)
- Children's National (US)
- University of Alberta (CA)
- University of Cape Town (ZA)
- Tel Aviv University (IL)
- University of Toronto (CA)
- Vanderbilt University (US)
- SUNY Upstate Medical University (US)
- Kyoto University (JP)
- Manchester Academic Health Science Centre (GB)
- Sheba Medical Center (IL)
- Queen Elizabeth II Health Sciences Centre (CA)
- London Health Sciences Centre (CA)
- Women's and Children's Hospital (AU)
- Hospital for Sick Children (CA)
- McMaster Children's Hospital (CA)
- Nova Scotia Health Authority (CA)
- Princess Margaret Cancer Centre (CA)
- University of Alberta Hospital (CA)
- Aga Khan University Hospital (PK)
- University of Alabama at Birmingham (US)
- Morgan Adams Foundation (US)
- Laboratório Bacchi (BR)
- Women's & Children's Health Research Institute (AU)
- Osaka City General Hospital (JP)
- Brain Tumour Research (GB)
- Schneider Children's Medical Center (IL)
- Hospital Infantil Universitario Niño Jesús (ES)
- Hiroshima University Hospital (JP)
- Lurie Children's Hospital (US)
- University Children's Hospital Zurich (CH)
- Saitama International Medical Center (JP)
- South Australian Health and Medical Research Institute (AU)
- Children's Hospital Zagreb (HR)
- Centre hospitalier de l'Université Laval (CA)
- Centre for Cancer Biology (AU)
- Children's Healthcare of Atlanta (US)
- Children's Hospital of Western Ontario (CA)
- Murdoch Children's Research Institute (AU)
- BC Children's Hospital (CA)
- Stollery Children's Hospital (CA)
- Neurological Surgery (US)
- Royal Manchester Children's Hospital (GB)
- Université Laval (CA)
- University of Colorado Anschutz Medical Campus (US)
- Nagoya University (JP)
- Nara Medical University (JP)
- University of Pennsylvania (US)
- Saitama Medical University (JP)
- Vanderbilt University Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Journal of Neurosurgery Pediatrics
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3171/2025.8.peds25160
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00