Macrophage-Derived Transcriptional Signatures Predict Prognosis and Drug Sensitivity in Thyroid Cancer: Integrative Analysis and Experimental Validation of SMYD3
This study identifies a tumor-enriched macrophage subpopulation with prognostic relevance and develops a robust machine learning-based model for risk stratification in thyroid cancer. SMYD3 is implicated in both tumor progression and drug sensitivity, offering a potential biomarker for precision treatment strategies.
Authors
- Sufang Xu (ORCID: https://orcid.org/0009-0004-6512-0502)
- Man Qin
- Jingru Sun
- Bing Luo
- Huarong Du
- Xin Zhang
Institutions
- Anhui Provincial Hospital (CN)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/itt.s565624
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00