Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging
This study provides the first integrative single-cell transcriptomic map of microglial-myeloid interactions after TBI across multiple tissues and time points, linking microglial signaling to mitochondrial dysfunction and neuroinflammation. These findings lay the foundation for therapeutic strategies targeting myeloid-driven immune regulation in TBI.
Authors
- Liang Gu
- Lixin Liu (ORCID: https://orcid.org/0000-0001-5556-7117)
- Chao Wu
- Ming Sun
- Xue Yang
- Zihao Wang
- Jingjing Wu
- Feng Xu
Institutions
- Xuzhou Medical College (CN)
- Soochow University (CN)
- Nanjing Drum Tower Hospital (CN)
- Shenzhen Children's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fnagi.2025.1657523
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00