The Utility of Mucin 2 and Caudal-Type Homeobox Transcription Factor 2 Expression in the Diagnosis of Barrett's Esophagus: A Community-Based Study of Wide-Area Transepithelial Sampling and Forceps Biopsies
MUC2 immunohistochemistry may be more sensitive and specific for diagnosing BE than goblet cells by FB. FB misses approximately half of BE when using MUC2/WATS3D as an alternative gold standard. The addition of MUC2 immunohistochemistry may aid in the recognition of BE.
Authors
- Arvind J. Trindade (ORCID: https://orcid.org/0000-0002-4132-0014)
- Mendel E. Singer (ORCID: https://orcid.org/0000-0002-3331-3340)
- Robert D. Herman (ORCID: https://orcid.org/0000-0002-1682-9572)
- Walker D. Redd (ORCID: https://orcid.org/0000-0003-0908-889X)
- Amit Aravapalli
- Maxx B. Cadmus
- Natalie Wilson (ORCID: https://orcid.org/0000-0003-1648-3310)
- Mark M. Smith (ORCID: https://orcid.org/0000-0003-4153-4335)
- Robert D. Odze (ORCID: https://orcid.org/0000-0001-7910-8273)
- William J. Salyers (ORCID: https://orcid.org/0000-0001-6666-5484)
- Matthew McKinley (ORCID: https://orcid.org/0000-0003-0331-6126)
- Sachin Srinivasan
- Nicholas J. Shaheen
- F. Scott Corbett
- Dan Lister
- Vivek Kaul
Institutions
- University of North Carolina at Chapel Hill (US)
- Tufts Medical Center (US)
- Northwell Health (US)
- University of Kansas (US)
- Wright State University (US)
- Long Island Jewish Medical Center (US)
- Northrop Grumman (United States) (US)
- Florida Digestive Health Specialists (US)
- PRN of Kansas (US)
- Asperger/Autism Network (US)
- Arkansas Heart Hospital (US)
- University of Rochester (US)
- New York University (US)
- Case Western Reserve University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.14309/ajg.0000000000003904
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00