Association between oxidative stress-related IGF-1 and prognosis after ischemic stroke: a systematic review and meta-analysis

This systematic review and meta-analysis suggests that oxidative stress-related IGF-1 may be associated with long-term unfavorable outcomes following ischemic stroke, particularly beyond 1 year after onset. However, no significant associations were found with the incidence of acute ischemic stroke or short-term outcomes. Given the observational nature of the included studies and inconsistencies in adjustment for confounders, these findings should be interpreted cautiously. IGF-1 may serve as a potential prognostic biomarker for long-term functional decline after stroke, but further large-scale prospective studies are needed to clarify causality and clinical applicability.