Clinical and dosimetric dataset of time-to-event normal tissue complication probability for osteoradionecrosis
Osteoradionecrosis of the jaw (ORNJ) is a radiation-induced late toxicity that can dramatically decrease patients' quality of life. Recent increases in survival rates of head and neck cancers associated with human papillomavirus (HPV) infection have resulted in a higher frequency of radiation-induced toxicities, particularly ORNJ. Recent work with Normal Tissue Complication Probability (NTCP) models and a Weibull Accelerated Failure Time (WAFT) model have further developed our understanding of ORNJ clinical/dosimetric risk factors and longitudinal features, respectively. In this data descriptor, 1129 head and neck cancer (HNC) patients received curative intent radiotherapy (RT) at MD Anderson Cancer Center and were followed up with clinical and radiological assessments at 3-6, 12, 18, 24 months, and then annually following the conclusion of RT for development of ORNJ. This data, in addition to the patients' demographic, supplementary clinical, and dosimetric information was recorded in a comma-separated value file embedded within this data descriptor. This large, longitudinal dataset is a significant resource for further systematic analysis of post-RT normal tissue outcomes in HNC.
Authors
- Lisanne V. van Dijk (ORCID: https://orcid.org/0000-0002-9515-5616)
- R. He
- John C. Robinson (ORCID: https://orcid.org/0009-0004-8226-1884)
- N. West
- Mark S. Chambers (ORCID: https://orcid.org/0000-0001-8901-6583)
- Stephen Y. Lai (ORCID: https://orcid.org/0000-0001-8301-7286)
- Moamen R. Abdelaal
- Mohamed A. Naser
- Kristy K. Brock
- Zaphanlene Kaffey
- Ruth Aponte-Wesson
- Melissa M. Chen
- Clifton D. Fuller
- Amy C. Moreno
- Guadalupe Canahuate
- Laia Humbert-Vidan
- Abdallah S. R. Mohamed
- G. Elisabeta Marai
- Katherine A. Hutcheson
- Xinhua Zhang
- Andrew Wentzel
Institutions
- University of Iowa (US)
- University Medical Center Groningen (NL)
- The University of Texas MD Anderson Cancer Center (US)
- Emory University (US)
- Baylor College of Medicine (US)
- University of Illinois Chicago (US)
- Vall d'Hebron Institut de Recerca (ES)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Scientific Data
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1038/s41597-025-06321-w
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Cancer Prevention and Research Institute of Texas
- University of Texas Health Science Center at Houston
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- National Institutes of Health
- University of Illinois at Urbana-Champaign
- University of Texas MD Anderson Cancer Center
- Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston
- National Cancer Institute
- National Institute of Dental and Craniofacial Research