Perampanel Blocks Transsynaptic α‐Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease
Perampanel could be a disease-modifying drug for Lewy body disease that modulates transsynaptic α-synuclein propagation, presumably by suppressing dynamin-dependent endocytosis. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- R. Matsumoto
- Miki Oono
- Tetsuya Hirato
- Tomoyuki Ishimoto (ORCID: https://orcid.org/0000-0001-8988-3898)
- Jun Ueda (ORCID: https://orcid.org/0000-0002-9766-203X)
- Jiarui Chang
- Norihito Uemura
- Hodaka Yamakado
- Shuichi Matsuzawa
Institutions
- Kyoto University (JP)
- Osaka Neurological Institute (JP)
Publication Details
- Journal
- Movement Disorders
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1002/mds.70191
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Moonshot Research and Development Program