The Effect of Chronotherapy on Clinical Outcomes in Hypertensive Patients: A Systematic Review and Meta‐Analysis Comparing Bedtime Versus Morning Dosing of Antihypertensive Drugs
This meta-analysis found no significant difference in cardiovascular outcomes between bedtime and morning antihypertensive dosing. Within the limitations of the available evidence, a universal chronotherapy strategy does not appear to provide additional cardiovascular benefit. Once-daily antihypertensive medications can be taken at a time that aligns with the patient's lifestyle, with adherence being the most critical factor in ensuring treatment effectiveness.
Authors
- Alireza Hosseinpour (ORCID: https://orcid.org/0000-0002-4175-8059)
- Farshad Rajabi
- Pouria Azami (ORCID: https://orcid.org/0000-0001-8563-6005)
- Alireza Mirhosseini
- Ehsan Zandi (ORCID: https://orcid.org/0009-0009-4447-4287)
- Armin Attar
- Sarvenaz Farhangdoust
Institutions
- Shiraz University of Medical Sciences (IR)
Publication Details
- Journal
- Health Science Reports
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/hsr2.71739
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00