Skin pharmacokinetics and pharmacodynamics in patients with post-kala-azar dermal leishmaniasis

Similar skin PK target attainment and relative parasite reduction were achieved for all regimens. Regional differences in parasite load and lesion score at baseline and lesion healing rates, suggest disease presentation is the primary factor affecting clinical outcomes.

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Publication Details

Journal
International Journal of Antimicrobial Agents
Published
2026-01-09
DOI
https://doi.org/10.1016/j.ijantimicag.2026.107713
Citations
1
Primary Topic
Research on Leishmaniasis Studies
Type
article
Field-Weighted Citation Impact
41.85
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article

Skin pharmacokinetics and pharmacodynamics in patients with post-kala-azar dermal leishmaniasis

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1 citations
International Journal of Antimicrobial Agents
Research on Leishmaniasis Studies
41.85
article

Skin pharmacokinetics and pharmacodynamics in patients with post-kala-azar dermal leishmaniasis

Wan-Yu Chu, Eltahir Awad Gasim Khalil, Shomik Maruf, José Carlos Solana, Andrew S. Torres, Prince Kumar, Fabiana Alves, Carmen J Silva Sanchez, Rahul Chaubey, Mujahid Ahmed Ali, Ahmed Musa, Mohammed Abdelrahim Saeed, Brima M. Younis, Ali Noureldin, Md Utba Rashid, Sheeraz Raja, Prakash Ghosh, Shyam Sundar, Deepak Kumar Verma, Javier Moreno, Pradeep Das, Eugenia Carrillo, Dinesh Mondal, Jaya Chakravarty, Vinod Kumar, Krishna Kumar Pandey, Joelle Rode, Ashish Kumar, Ignace C. Roseboom, Major Madhukar, Thomas P.C Dorlo, Om Prakash Singh, Lorena Bernardo, Abhishek Kumar Singh, Anas Elbashir Ahmed
article en
1 citations

Abstract

Similar skin PK target attainment and relative parasite reduction were achieved for all regimens. Regional differences in parasite load and lesion score at baseline and lesion healing rates, suggest disease presentation is the primary factor affecting clinical outcomes.

International Journal of Antimicrobial AgentsVol. 67(3)
Uppsala University (SE), Drugs for Neglected Diseases Initiative (CH), Rajendra Memorial Research Institute of Medical Sciences (IN), University of Khartoum (SD), International Centre for Diarrhoeal Disease Research (BD), Instituto de Salud Carlos III (ES), The Netherlands Cancer Institute (NL), ICAR – National Research Centre on Litchi (NP), Drugs for Neglected Diseases Initiative India (IN), Oncode Institute (NL), Ludwig Cancer Research (SE), National Institute of Research in Tuberculosis (IN), Institute of Medical Sciences (IN), Banaras Hindu University (IN)
Good health and well-being
Openalex Percentile: Top 2%
Research on Leishmaniasis Studies
41.85
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