Application Research of Targeted Next-Generation Sequencing Technology Based on Bronchoalveolar Lavage Fluid in the Diagnosis of Pulmonary Tuberculosis and Drug-Resistance Detection
tNGS provides excellent diagnostic accuracy for PTB and reliable detection of drug-resistant mutations from BALF samples. It is particularly suitable for smear-negative cases and for resistance screening, making it a powerful complement to the existing TB diagnosis system with high clinical application potential.
Authors
- Chun-Mei Zeng (ORCID: https://orcid.org/0000-0003-1977-8763)
- Q. Tan (ORCID: https://orcid.org/0000-0003-2012-1603)
- Xuewen Huang (ORCID: https://orcid.org/0000-0001-9382-2991)
- Ai-Chun Huang
- Qingdong Zhu (ORCID: https://orcid.org/0009-0003-3368-5296)
- Chang W. Song
- Changyue Jiang (ORCID: https://orcid.org/0009-0008-5881-5823)
- Chun-Yan Zhao
- Xiao-Shi Lin
- Wei-Wen Li
- Zhen-Tao Huang
Institutions
- Guangxi Medical University (CN)
- The Fourth People's Hospital (CN)
- The Second Nanning People's Hospital (CN)
- First People's Hospital of Nanning (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/idr.s567798
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangxi Key Research and Development Program