The Hepatic Zonation Paradox Why Zone 3 Cells Are Both Most Vulnerable and Most Regenerative

Liver injury preferentially affects Zone 3 (pericentral) hepatocytes due tochronic hypoxia pO = 30-35 mmHg, yet these same cells exhibit the fastest regenerativeresponse post-injury. This paradox has remained mechanistically unexplained.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-05
DOI
https://doi.org/10.5281/zenodo.18154556
Primary Topic
Liver physiology and pathology
Type
article
Field-Weighted Citation Impact
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article

The Hepatic Zonation Paradox Why Zone 3 Cells Are Both Most Vulnerable and Most Regenerative

Ionut Alexandru Stefan
Zenodo (CERN European Organization for Nuclear Research)
Liver physiology and pathology
article

The Hepatic Zonation Paradox Why Zone 3 Cells Are Both Most Vulnerable and Most Regenerative

Ionut Alexandru Stefan
article en

Abstract

Liver injury preferentially affects Zone 3 (pericentral) hepatocytes due tochronic hypoxia pO = 30-35 mmHg, yet these same cells exhibit the fastest regenerativeresponse post-injury. This paradox has remained mechanistically unexplained.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 94%
Liver physiology and pathology
DOIOpen Access PDFOpenAlex
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The Hepatic Zonation Paradox Why Zone 3 Cells Are Both Most Vulnerable and Most Regenerative — Ionut Alexandru Stefan · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS