Locus coeruleus alterations in dementia with Lewy bodies: A systematic review
Locus coeruleus (LC) alterations are among the earliest changes in dementia with Lewy bodies (DLB).Accumulation of α-synuclein in the LC disrupts noradrenergic function.LC neurodegeneration may contribute to cognitive and neuropsychiatric symptoms.Neuromelanin-sensitive magnetic resonance imaging (NM-MRI) reveals LC signal loss from the prodromal stage of DLB.LC dysfunction emerges as a potential biomarker and therapeutic target in DLB.
Authors
- Charlotte Toméo
- Claire André (ORCID: https://orcid.org/0000-0001-9600-7124)
- Robin de Flores
- Anaëlle Bain
- Antoine Garnier‐Crussard
- Sophie Dautricourt
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Sorbonne Université (FR)
- Centre de Recherche en Neurosciences de Lyon (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospices Civils de Lyon (FR)
- Normandie Université (FR)
- Cyceron (FR)
- Hôpital Tenon (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/trc2.70199
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00