High salt-induced osmotic stress differentially modulates hepatocellular and renal carcinoma cell proliferation
Taken together, these findings indicate the potential role of osmotic stress tolerance in the differential effects of hypertonic environments on HepG2 and Caki-1 cell proliferation, highlighting NFAT5 and associated osmoadaptive mechanisms as promising therapeutic targets within the tumor microenvironment.
Authors
- Akira Nishiyama (ORCID: https://orcid.org/0000-0002-8802-3770)
- Yoshihiro Nakajima (ORCID: https://orcid.org/0000-0002-7422-730X)
- Kento Kitada
- Changjin Liu
- Xi Chen
- Asadur Rahman
- Yaoyu Wang
- Rikiya Taoka
Institutions
- Kagawa University (JP)
- National Institute of Technology, Kagawa College (JP)
- National Institute of Advanced Industrial Science and Technology (JP)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fonc.2025.1693591
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science