14 01 Base Architecture Colorectal Carcinoma MSI-H dMMR

CMS1 (MSI-high) colorectal cancer represents a unique ecosystem where genomic instability (microsatellite instability) creates massive neoantigen burden, paradoxically triggering intense immuneinfiltration while maintaining tumor survival through incompletely understood mechanisms. Traditional analyses focus on isolated aspects—genomics OR immunology OR metabolism—missing theemergent properties arising from their integration.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-06
DOI
https://doi.org/10.5281/zenodo.18166648
Primary Topic
Genetic factors in colorectal cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

14 01 Base Architecture Colorectal Carcinoma MSI-H dMMR

Ionut Alexandru Stefan
Zenodo (CERN European Organization for Nuclear Research)
Genetic factors in colorectal cancer
article

14 01 Base Architecture Colorectal Carcinoma MSI-H dMMR

Ionut Alexandru Stefan
article en

Abstract

CMS1 (MSI-high) colorectal cancer represents a unique ecosystem where genomic instability (microsatellite instability) creates massive neoantigen burden, paradoxically triggering intense immuneinfiltration while maintaining tumor survival through incompletely understood mechanisms. Traditional analyses focus on isolated aspects—genomics OR immunology OR metabolism—missing theemergent properties arising from their integration.

Zenodo (CERN European Organization for Nuclear Research)
Life in Land
Openalex Percentile: Top 93%
Genetic factors in colorectal cancer
DOIOpen Access PDFOpenAlex
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14 01 Base Architecture Colorectal Carcinoma MSI-H dMMR — Ionut Alexandru Stefan · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS