C-X-C motif chemokine ligand 13 suppresses osteoclast differentiation via interference with RANKL–RANK interaction

These findings identify CXCL13 as a novel suppressor of osteoclastogenesis by interfering with RANKL-RANK signaling, unveiling an unrecognized regulatory role in osteoclast biology and suggesting potential therapeutic relevance for bone loss disorders.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-09
DOI
https://doi.org/10.3389/fimmu.2025.1729222
Primary Topic
Bone Metabolism and Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

C-X-C motif chemokine ligand 13 suppresses osteoclast differentiation via interference with RANKL–RANK interaction

David Achudhan, Chun-Lin Liu, Jeng-Hung Guo, Chih-Hsin Tang et al.
Frontiers in Immunology
Bone Metabolism and Diseases
article

C-X-C motif chemokine ligand 13 suppresses osteoclast differentiation via interference with RANKL–RANK interaction

David Achudhan, Chun-Lin Liu, Jeng-Hung Guo, Chih-Hsin Tang, Le Huynh Hoai Thuong, Chien-Tai Ren, Kun-Tsan Lee, Chih-Yuan Ko, Yu-Hao He, Trung-Loc Ho
article en

Abstract

These findings identify CXCL13 as a novel suppressor of osteoclastogenesis by interfering with RANKL-RANK signaling, unveiling an unrecognized regulatory role in osteoclast biology and suggesting potential therapeutic relevance for bone loss disorders.

Frontiers in ImmunologyVol. 16
Mayo Clinic (US), Asia University (TW), National Chung Hsing University (TW), China Medical University (TW), Taichung Veterans General Hospital (TW), Mayo Clinic in Arizona (US), China Medical University Hospital (TW), Mayo Clinic in Florida (US)
Openalex Percentile: Top 93%
Bone Metabolism and Diseases
DOIOpen Access PDFOpenAlex
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C-X-C motif chemokine ligand 13 suppresses osteoclast differentiation via interference with RANKL–RANK interaction — David Achudhan, Chun-Lin Liu, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS