Drug repurposing of Nifuratel against methicillin-resistant Staphylococcus aureus through proton motive force disruption

These results identify Nifuratel as a promising repurposed antimicrobial agent against MRSA. Its dual capability to exert direct bactericidal activity by disrupting PMF and attenuate key virulence factors, combined with a favorable resistance profile and biocompatibility <i>in vivo</i>, supports its potential for further therapeutic development.

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Publication Details

Journal
Frontiers in Cellular and Infection Microbiology
Published
2026-01-09
DOI
https://doi.org/10.3389/fcimb.2025.1738031
Primary Topic
Antimicrobial Resistance in Staphylococcus
Type
article
Field-Weighted Citation Impact
0.00

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article

Drug repurposing of Nifuratel against methicillin-resistant Staphylococcus aureus through proton motive force disruption

Di Zhang, Bingqin Qin, Kening Lin
Frontiers in Cellular and Infection Microbiology
Antimicrobial Resistance in Staphylococcus
article

Drug repurposing of Nifuratel against methicillin-resistant Staphylococcus aureus through proton motive force disruption

Di Zhang, Bingqin Qin, Kening Lin
article en

Abstract

These results identify Nifuratel as a promising repurposed antimicrobial agent against MRSA. Its dual capability to exert direct bactericidal activity by disrupting PMF and attenuate key virulence factors, combined with a favorable resistance profile and biocompatibility <i>in vivo</i>, supports its potential for further therapeutic development.

Frontiers in Cellular and Infection MicrobiologyVol. 15
Central South University (CN), Chenzhou First People's Hospital (CN), Third Xiangya Hospital (CN)
National Natural Science Foundation of China, Central South University, China National Tobacco Corporation, Xiangya Hospital, Central South University
Good health and well-being
Openalex Percentile: Top 95%
Antimicrobial Resistance in Staphylococcus
DOIOpen Access PDFOpenAlex
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Drug repurposing of Nifuratel against methicillin-resistant Staphylococcus aureus through proton motive force disruption — Di Zhang, Bingqin Qin, et al. · Frontiers in Cellular and Infection Microbiology (2026) | TGRS Research Map | TGRS