Targeted demethylation of the BRD7 promoter based on CRISPR/dCas9 system inhibits the malignant progression of nasopharyngeal carcinoma
The hypermethylation modification of BRD7 is an important mechanism leading to the inactivation of BRD7, and targeting demethylation of BRD7 inhibits the malignant progression of NPC, which might be a promising targeted therapeutic approach for treating NPC.
Authors
- Changning Xue
- Jianxia Wei (ORCID: https://orcid.org/0000-0002-0891-3088)
- Huizhen Xin (ORCID: https://orcid.org/0000-0002-2201-6949)
- Zhaoyang Zeng
- Lemei Zheng
- MengNa Li
- Zi-you Wu (ORCID: https://orcid.org/0000-0002-6780-9870)
- Maosong Zhou (ORCID: https://orcid.org/0000-0002-6111-1228)
- Songqing Fan
- Deng Hy
- Qingqing Wei
- Ting Zeng
- Wei Xiong
- Yumei Duan
Institutions
- Central South University (CN)
- Ministry of Education (SA)
- Hunan Cancer Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/ctm2.70583
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00