Inhibition of Retinal AdoRA2a Activity Attenuates Myopia Progression
Our results demonstrate that retinal AdoRA2a plays a pivotal role in myopia progression. Our findings identify the retina as the critical site for AdoRA2a's action and suggest an underlying AdoRA2a-Drd2 interaction mechanism, revealing the possible therapeutic potential of KW6002 in myopia progression.
Authors
- W. Chen
- Q Wang
- Fuxin Zhao
- Juan Lu (ORCID: https://orcid.org/0000-0001-5635-3233)
- Shengcong Liu
- Xingxing Yang (ORCID: https://orcid.org/0000-0002-3170-1868)
- Wei Qu
- Furong Huang (ORCID: https://orcid.org/0000-0001-8760-439X)
- Jia Qu
- Wenting Li
- Yixin Zhou
- Miaozhen Pan
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Shanghai Ninth People's Hospital (CN)
- Ministry of Industry and Information Technology (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1167/iovs.67.1.15
- Primary Topic
- Ophthalmology and Visual Impairment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00