Genomic Landscape Reveals Correlation of Endosymbiont <i>Ralstonia</i> With <i>Acanthamoeba</i> Keratitis Severity
Whole-genome sequencing highlighted the symbiotic relationship between Acanthamoeba and associated microorganisms. The presence of the endosymbiont Ralstonia influenced the biological characteristics of Acanthamoeba and was correlated with clinical poor prognosis in AK, suggesting its potential as a target for clinical intervention.
Authors
- Jinding Pang (ORCID: https://orcid.org/0009-0007-8573-9240)
- Qiankun Chen
- Zhenyu Wei (ORCID: https://orcid.org/0000-0001-5072-1883)
- Zijun Zhang (ORCID: https://orcid.org/0000-0001-8269-6854)
- Yuxi Zhang (ORCID: https://orcid.org/0000-0003-3558-2939)
- Qingquan Shi (ORCID: https://orcid.org/0000-0002-2094-6958)
- Yuan Wei
- Y G Peng
- M D Zhou
- Jiamin Liu (ORCID: https://orcid.org/0000-0003-0118-4852)
- Zhiqun Wang
- Kexin Chen
- Xizhan Xu
- Xinxin Lu
- Qingfeng Liang
- Yang Zhang
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1167/iovs.67.1.17
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Institute of Microbiology, Chinese Academy of Sciences