Population Analysis and Immunologic Landscape of Melanoma in People Living with HIV
Melanoma in PLWH is associated with distinct clinical and immunologic features, including delayed ICI treatment, reduced survival, and an immunosuppressive microenvironment with exhausted CD8+ T cells and expanded MDSCs. These findings suggest that chronic HIV infection may impair antitumor immunity in melanoma. Targeting the pathways identified here may improve therapeutic responses and outcomes in this population.
Authors
- Peter J. Gaskill (ORCID: https://orcid.org/0000-0003-0095-5424)
- Gabriele Romano (ORCID: https://orcid.org/0000-0001-8023-8657)
- Rino S. Seedor (ORCID: https://orcid.org/0000-0002-8494-3289)
- Lindsay N. Barger (ORCID: https://orcid.org/0000-0001-8939-092X)
- Madalina Tuluc (ORCID: https://orcid.org/0000-0003-4920-3901)
- Jennifer Louise Hope
- Gyles Ward (ORCID: https://orcid.org/0000-0002-3129-2523)
- Derek Wang
- Iman Dehzangi
- Ashley Saravia
- Carly Feldman
- George Jour
- Cynthia Loomis
- Anna E. Coghill
- Valeria Mezzano
- Gita Suneja
Institutions
- Rutgers, The State University of New Jersey (US)
- Thomas Jefferson University Hospital (US)
- Huntsman Cancer Institute (US)
- Moffitt Cancer Center (US)
- NYU Langone Health (US)
- Sidney Kimmel Cancer Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Drexel University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-3148
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Melanoma Research Alliance
- Sidney Kimmel Comprehensive Cancer Center
- National Institute of Mental Health
- National Cancer Institute
- Congressionally Directed Medical Research Programs