Plasma levels of an N‐terminal tau fragment predict Alzheimer's and neurodegenerative disease biomarkers in autosomal dominant Alzheimer's disease
Leveraging a deeply phenotyped cohort of individuals carrying a pathogenic variant for autosomal dominant Alzheimer's disease (ADAD) and their non-carrier family members, our results suggest that plasma N-terminal tau fragment 1 (NT1) levels mirrored changes in clinical, cognitive, and neurodegenerative measures in ADAD, particularly in late asymptomatic and early symptomatic phases of disease. NT1 levels correlated with cerebrospinal fluid (CSF) measures of tau pathology but less so with CSF or imaging measures of β-amyloid pathology. Together with previous supportive findings in preclinical and symptomatic sporadic AD, these results suggest that plasma NT1-alone or combined with other tau measures-may be useful in studying AD-related tau pathology and neurodegeneration across a wide spectrum of disease.
Authors
- L Liu
- Yi Rao (ORCID: https://orcid.org/0000-0002-0405-5426)
- Zahra Shirzadi (ORCID: https://orcid.org/0000-0001-6854-9356)
- Wai‐Ying Wendy Yau (ORCID: https://orcid.org/0000-0002-7597-7647)
- Amirah K. Anderson (ORCID: https://orcid.org/0009-0002-5612-3838)
- Beth L. Ostaszewski
- DO Eric McDade
- J. Newman Morris
- Salvador M. Guinjoan
- Jasmeer P. Chhatwal
- Dennis J. Selkoe
- Gregory S. Day
- Jason Hassenstab
- Richard J. Perrin
- Johannes Levin
- Mathias Jucker
- Randall J. Bateman
- Nick Fox
- Brian A. Gordon
- Reisa A. Sperling
- Hiroshi Mori
- Stephanie A. Schultz
- Nicolas R. Barthélemy
- Peter Schofield
- Allan I. Levey
- and the Dominantly Inherited Alzheimer's Network
- Stephen Salloway
Institutions
- Brigham and Women's Hospital (US)
- Emory Healthcare (US)
- Harvard University (US)
- Emory University (US)
- Washington University in St. Louis (US)
- German Center for Neurodegenerative Diseases (DE)
- Jacksonville College (US)
- Butler Hospital (US)
- LMU Klinikum (DE)
- UNSW Sydney (AU)
- Massachusetts General Hospital (US)
- Emory Clinic (US)
- Center for Neuro-Oncology (US)
- Munich Cluster for Systems Neurology (DE)
- Instituto de Neurología Cognitiva (AR)
- Emory Rehabilitation Hospital (US)
- UK Dementia Research Institute (GB)
- Mayo Clinic in Florida (US)
- University College London (GB)
- Ludwig-Maximilians-Universität München (DE)
- The University of Osaka (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/alz.71049
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Brigham and Women's Hospital
- Japan Agency for Medical Research and Development
- Korea Health Industry Development Institute
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Ministry of Science and ICT, South Korea
- Fleni
- National Institutes of Health
- Instituto de Salud Carlos III
- National Institute on Aging