Adipokine levels and depression in individuals aged ≥ 90 years: is there an association?

The aim of the study was to investigate the relationship between adipokine levels (adiponectin and resistin) and depressive affect in individuals aged 90 and over. The study included 90 individuals of both sexes aged between 90 and 103 years (mean = 92.36; SD = 2.98). The study was based on a diagnostic survey, administered through face-to-face interviews. The prevalence of depression in the study group was assessed using a screening test, the 15-item Geriatric Depression Scale (GDS). Blood samples were collected in accordance with the relevant regulations and procedures for the collection, storage and transport of biological material. All patients were thoroughly informed about the scope and objectives of the study and gave their written consent to participate. Univariate analysis revealed a link between elevated resistin levels (OR = 1.254 p = 0.006) and depression. In multivariate analysis, after adjusting for potential confounders, resistin levels > 6.95 remained significantly associated with an increased likelihood of depression (OR = 5.394, p = 0.001). The results of the study indicate that higher serum resistin levels are associated with depressive symptoms in individuals aged 90 years and older, independently of metabolic, inflammatory, and hormonal factors. These findings provide preliminary evidence of a potential link between resistin and depressive affect in the oldest-old population; however, due to the study’s design, causality or temporal sequence cannot be determined.