Modified Shen-Yan-Fang-Shuai formula attenuates diabetic kidney disease progression via regulation of HIF-1α-mediated mitochondrial energy metabolism
M-SYFSF exerts significant nephroprotective effects in diabetic kidney disease by targeting HIF-1α-mediated metabolic reprogramming. The therapeutic mechanisms involve suppression of pathological glycolytic metabolism, restoration of mitochondrial function and dynamics, and enhancement of antioxidant capacity. These findings provide mechanistic validation for M-SYFSF as a promising multi-target therapeutic approach for diabetic kidney disease management and establish HIF-1α as a key therapeutic target for metabolic intervention in DKD treatment.
Authors
- J. Cheng-Chung Wei (ORCID: https://orcid.org/0009-0003-8880-2322)
- Yaotan Li
- Xiaochang Wu
- Huijuan Zheng (ORCID: https://orcid.org/0000-0002-0389-3989)
- Jinyi Hou
- Yizhen Han
- Xinghua Zhang
- Weijing Liu
- Bingnan Di
Institutions
- Shanxi Medical University (CN)
- Beijing University of Chinese Medicine (CN)
- Shenyang Anorectal Hospital (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Henan University (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1186/s13020-025-01298-5
- Citations
- 1
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 34.94