Risk factors and clinical implications of thyroxine replacement therapy on major adverse cardiovascular events in type 2 diabetes: a retrospective cohort study
In participants receiving thyroxine with diabetes, patients with worse renal function, hypertension, history of diabetic microvascular complications, ESRD, CHD, heart failure, CVA, and diabetic foot infection had a higher risk of experiencing MACE, but peripheral artery disease (PAD) was not a significant risk of MACE.
Authors
- Chia-Hung Lin
- Chih-Wei Hsu
- Pi-Hua Liu
- Yi-Hsuan Lin
Institutions
- Chang Gung University (TW)
- Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fendo.2025.1721865
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chang Gung Medical Foundation
- Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital
- Center for Big Data Analytics, University of Texas at Austin