CCL5/RANTES signaling in inflammation dysregulation after mild traumatic brain injury
These findings demonstrate that CCL5 modulates microglial polarization and attenuates oxidative stress in the injured brain through a CCR5-dependent mechanism. Targeting the CCL5-CCR5 signaling axis may offer a promising therapeutic strategy for improving outcomes after mTBI.
Authors
- Y. Wang
- Szu-yi Chou
- Man-Hau Ho (ORCID: https://orcid.org/0000-0001-9488-1168)
- Y. L. Lee
- J. W. Wang
- Cheng-Yeh Lee (ORCID: https://orcid.org/0000-0002-7145-2026)
- Barry J. Hoffer (ORCID: https://orcid.org/0000-0002-1122-9025)
- Chia-Hung Yen
- Thierry Burnouf
- Yih-Jeng Tsai
- Wen-Cheng Lin
- Yi-Chen Hsieh
Institutions
- Fu Jen Catholic University (TW)
- National Institutes of Health (US)
- National Health Research Institutes (TW)
- National Pingtung University of Science and Technology (TW)
- Taipei Medical University Hospital (TW)
- RED Consulting (Norway) (NO)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1186/s12929-025-01203-0
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 30.63