Enhancing the tumoricidal efficacy of the nanobubbles-mediated PD-L1 inhibition and immunogenic cell death in mice
The study demonstrated that miR-497/SK-loaded nanobubbles simultaneously boosts ICD and blocks the PD-1/PD-L1 pathway in immunotherapy. This finding offers a theoretical foundation for the effective eradication of tumor cells and the development of a highly efficient synergistic treatment strategy for HCC.
Authors
- Yezi Chen
- Jiaxuan Han
- Chang Zhou
- Rong Liu
- Yao Ma
- Yun Zhao
- Yun Liu
- Shiqi Yang
- Chaoqi Liu
- Yu Hu
Institutions
- China Three Gorges University (CN)
- Shanxi Medical University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Yichang Central People's Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1672324
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00