Response to High‐Dose Topical Capsaicin in Neuropathic Pain: Absence of Deep Pain as a Predictor of Analgesic Effect

This exploratory study identifies promising predictors for analgesic response to high-concentration capsaicin. The models generated in this study include a spectrum of different variables considering psychological factors as well as functional nerve-fibre assessments and genetic polymorphisms.

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Publication Details

Journal
European Journal of Pain
Published
2026-01-01
DOI
https://doi.org/10.1002/ejp.70200
Primary Topic
Pain Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
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article

Response to High‐Dose Topical Capsaicin in Neuropathic Pain: Absence of Deep Pain as a Predictor of Analgesic Effect

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Response to High‐Dose Topical Capsaicin in Neuropathic Pain: Absence of Deep Pain as a Predictor of Analgesic Effect

S Brügge, Andreas Dunst, Henrike Bruckmüller, Janne Gierthmühlen, Stefanie Rehm, Dilara Kersebaum, Julia Forstenpointner, Jan Vollert, Lena Ehmke, Manon Sendel, Ingolf Cascorbi, R. Baron
article en

Abstract

This exploratory study identifies promising predictors for analgesic response to high-concentration capsaicin. The models generated in this study include a spectrum of different variables considering psychological factors as well as functional nerve-fibre assessments and genetic polymorphisms.

European Journal of PainVol. 30(1)
University of Exeter (GB), University Hospital Schleswig-Holstein (DE), UiT The Arctic University of Norway (NO), University of Lübeck (DE)
Good health and well-being
Openalex Percentile: Top 94%
Pain Mechanisms and Treatments
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