Characterizing amyloid and tau positron emission tomography‐based stages across the clinical continuum
PET-based staging is feasible across multiple cohorts and PET tracers. There is heterogeneity in amyloid and tau severity across the clinical spectrum. The frequency of amyloid and tau PET severity increased with clinical severity. The likelihood of tau PET severity differed by age, amyloid, and clinical severity.
Authors
- Theresa Harrison
- Kyan Younes (ORCID: https://orcid.org/0000-0002-9912-1616)
- M. L. Cuccaro
- Karly Alex Cody (ORCID: https://orcid.org/0000-0001-5996-2560)
- Emily Johns (ORCID: https://orcid.org/0000-0003-2887-8272)
- DEREK ARCHER
- Christina B. Young (ORCID: https://orcid.org/0000-0001-9535-2137)
- Andrzej Sokołowski (ORCID: https://orcid.org/0000-0002-2787-6665)
- Aditi Sathe
- Philip S. Insel
- Andrew J. Saykin
- Mary Ellen I. Koran
- Lucah Medina Guerra
- Alaina Durant
- Elizabeth C. Mormino
- Joseph R. Winer
- Logan Dumitrescu
- Arthur W. Toga
- Jesse Mez
- Sterling C. Johnson
- Duygu Tosun
Institutions
- Boston University (US)
- University of Southern California (US)
- University of Wisconsin–Madison (US)
- University of Miami (US)
- University of California, San Francisco (US)
- Neurosciences Institute (US)
- University of California System (US)
- Mayo Clinic in Arizona (US)
- Stanford Medicine (US)
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
- University of California, Berkeley (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/alz.71017
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- University of Southern California
- Vanderbilt University
- University of Pennsylvania
- Emory University
- Northwestern University
- Alzheimer's Disease Neuroimaging Initiative
- University of Washington
- University of Pittsburgh
- Rush University
- National Institutes of Health