SERPINE1 maintained expression by NR4A1 promotes invasion and migration of glioblastoma in hypoxic microenvironment
This study provides new insights into the molecular mechanisms underlying the progression of GBM, emphasizing the role of SERPINE1 and its interaction with NR4A1 in promoting EMT and tumor invasion. Inhibiting the expression of SERPINE1 in GBM cells can prevent cell invasion, providing a potential strategy for the treatment of GBM.
Authors
- Zhennan Tao (ORCID: https://orcid.org/0000-0001-7630-2273)
- XY Zhang
- Bin Xu (ORCID: https://orcid.org/0000-0001-8934-3074)
- Wanli Yu
- Yimuran Yilamu
- Yuxiang Dai
- Chen Yu
- Yi Sun
Institutions
- Jiangxi University of Water Resources and Electric Power (CN)
- Nanchang University (CN)
- Jiangxi University of Technology (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Nanjing Drum Tower Hospital (CN)
- Jiangxi Agricultural University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fonc.2025.1750546
- Citations
- 1
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 23.21
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Basic Research Program of Jiangsu Province