Association of influenza viral genetic information with severity markers in patients hospitalised with influenza: multicentre retrospective cohort study
This analysis highlights the differential impact of influenza subtypes and clades on disease severity in hospitalised patients. Future research should investigate the role of specific viral mutations of these clades in modulating immune evasion or disease severity. These findings reinforce the GIHSN's critical role in global surveillance. Ongoing genomic surveillance is crucial for understanding the clinical impact of emerging influenza variants and informing public health responses.
Authors
- Burtseva Ei (ORCID: https://orcid.org/0000-0003-2518-6801)
- Hig Giamberardino
- A Mira-Iglesias
- Alejandro Orrico‐Sánchez (ORCID: https://orcid.org/0000-0002-3780-3187)
- C. CHAUVEL
- Alla Mironenko (ORCID: https://orcid.org/0000-0002-2630-1827)
- Ndongo Dia (ORCID: https://orcid.org/0000-0002-4051-3797)
- Vicky L. Baillie (ORCID: https://orcid.org/0000-0003-1327-9090)
- George Shirreff
- Joseph Bresee
- Sominina Aa
- Mine Durusu Tanrıöver (ORCID: https://orcid.org/0000-0001-9565-4389)
- Melissa Andrew
- Wenqing Zhang (ORCID: https://orcid.org/0009-0005-5606-5641)
- Sonia Mara Raboni
- Lina Bruno
- Anca Cristina Drăgănescu
- Harm Van Bakel
- Justin R. Ortiz
- Antonin Bal
- Gregory Destras
- F Xavier López-Labrador
- Emilia Sordillo
- Nataliia Teteriuk
- Nancy A Otieno
- Laurence Josset
- Viviana Simon
- Serhat Unal
- Marta C Nunes
- Daouda Coulibaly
- Victor Alberto Laguna-Torres
- Jason J LeBlanc
- Oana Săndulescu
- Aung Pone Myint
- Ghassan Dbaibo
- Celina F Boutros
- Andrey B Komissarov
Institutions
- Université Claude Bernard Lyon 1 (FR)
- South African Medical Research Council (ZA)
- École Normale Supérieure de Lyon (FR)
- University of Maryland, Baltimore (US)
- World Health Organization - Pakistan (PK)
- Centre National de la Recherche Scientifique (FR)
- Dalhousie University (CA)
- Inserm (FR)
- Universitat de València (ES)
- Carol Davila University of Medicine and Pharmacy (RO)
- National University of San Marcos (PE)
- Sher-i-Kashmir Institute of Medical Sciences (IN)
- Fondation de France (FR)
- Instituto de Salud Carlos III (ES)
- Kenya Medical Research Institute (KE)
- Sorbonne Université (FR)
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Hospices Civils de Lyon (FR)
- World Health Organization (CH)
- Hospital Erasto Gaertner (BR)
- Ministry of Health (UA)
- Infectious Diseases Institute (UG)
- Ministry of Health of the Russian Federation (RU)
- Laboratoire de Physique Théorique et Hautes Energies (FR)
- The Task Force for Global Health (US)
- Institut Pasteur de Dakar (SN)
- Research Institute of Influenza (RU)
- Centre International de Recherche en Infectiologie (FR)
- Institut National d’Hygiène Publique (CI)
- Universidade Federal do Paraná (BR)
- Hacettepe University (TR)
- American University of Beirut (LB)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- BMJ Open
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1136/bmjopen-2025-111643
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00