Rationale and design of a randomized, sham-controlled, clinical trial for evaluation of the Edwards APTURE transcatheter shunt system (ALT-FLOW II)
The ALT-FLOW II trial will evaluate the safety and performance of the APTURE system in symptomatic HFpEF and HFmrEF patients with elevated left atrial pressure.
Authors
- S Windecker
- William A. Gray (ORCID: https://orcid.org/0000-0003-4676-2839)
- M Böhm
- João L. Cavalcante (ORCID: https://orcid.org/0000-0002-3632-2074)
- Rami Kahwash (ORCID: https://orcid.org/0000-0001-5009-2909)
- Suzanne J. Baron
- S. Mary Lilly
- B. Hibbert
- Javed Butler
- Robert A Harrington
- Dean J Kereiakes
- Phillip Lurz
- Ulrich P Jorde
- JoAnn Lindenfeld
- Firas Zahr
- Ryan J Tedford
- John R Teerlink
Institutions
- Main Line Health (US)
- San Francisco VA Medical Center (US)
- Medical University of South Carolina (US)
- Oregon Health & Science University (US)
- Johannes Gutenberg University Mainz (DE)
- Cornell University (US)
- University Hospital of Bern (CH)
- University of Mississippi (US)
- Massachusetts General Hospital (US)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Universitätsklinikum des Saarlandes (DE)
- Baim Institute for Clinical Research (US)
- Montefiore Health System (US)
- Mayo Clinic in Arizona (US)
- Minneapolis Heart Institute Foundation (US)
- Christ Hospital (US)
- Baylor Scott & White Health (US)
- Weill Cornell Medicine (US)
- The Ohio State University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1093/ejhf/xuaf016
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00