CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems

We developed CCorGsDB, a web-based resource integrating mouse and human CNS co-expression networks filtered by circadian biomarkers. We validated the networks using time-series data from sixteen mouse regions and identified a conserved set of 251 orthologs enriched for RNA processing, chromatin regulation, and autism-related phenotypes. The database links CCorGs to disease terms and short-half-life CNS-active drugs with spatially resolved profiles. CCorGsDB is available at https://famed.ufal.br/ccorgs .

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Publication Details

Journal
npj Biological Timing and Sleep
Published
2026-01-09
DOI
https://doi.org/10.1038/s44323-025-00064-y
Primary Topic
Circadian rhythm and melatonin
Type
article
Field-Weighted Citation Impact
0.00

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article

CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems

Daniel Gomes Coimbra, Vinícius Tenório Braga Cavalcante Pinto, José Luiz Araujo Santos, Thales Eduardo da Silva Santos et al.
npj Biological Timing and Sleep
Circadian rhythm and melatonin
article

CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems

Daniel Gomes Coimbra, Vinícius Tenório Braga Cavalcante Pinto, José Luiz Araujo Santos, Thales Eduardo da Silva Santos, Tiago Gomes de Andrade
article en

Abstract

We developed CCorGsDB, a web-based resource integrating mouse and human CNS co-expression networks filtered by circadian biomarkers. We validated the networks using time-series data from sixteen mouse regions and identified a conserved set of 251 orthologs enriched for RNA processing, chromatin regulation, and autism-related phenotypes. The database links CCorGs to disease terms and short-half-life CNS-active drugs with spatially resolved profiles. CCorGsDB is available at https://famed.ufal.br/ccorgs .

npj Biological Timing and SleepVol. 3(1)
Universidade Federal de Alagoas (BR)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico
Openalex Percentile: Top 92%
Circadian rhythm and melatonin
DOIOpen Access PDFOpenAlex
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