Hippocampal Asymmetry Captures Non–Amyloid-Related Risk of Memory Decline and Clinical Progression
Hippocampal total volume and asymmetry capture distinct aspects of neurodegeneration, with asymmetry providing additional prognostic information for memory decline and clinical progression in participants without detectable amyloid pathology.
Authors
- Davis C. Woodworth (ORCID: https://orcid.org/0000-0002-6256-857X)
- Lukai Zheng (ORCID: https://orcid.org/0000-0003-1328-2791)
- Elham Ghanbarian
- Crystal Glover
- Babak Khorsand
- Ali Ezzati
- Maria M. Corrada
- S. Ahmad Sajjadi
- Joshua D. Grill
Institutions
- University of California, Irvine (US)
- University Memory and Aging Center (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-08
- DOI
- https://doi.org/10.64898/2026.01.06.26343553
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- University of Southern California
- Meso Scale Diagnostics
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Hope Center for Neurological Disorders
- Texas Alzheimer's Research and Care Consortium
- Ministry of Science, ICT and Future Planning
- Servier
- H. Lundbeck A/S
- National Institutes of Health
- Canadian Institutes of Health Research
- Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis
- National Institute on Aging
- National Institute on Minority Health and Health Disparities