Comparative acceptability of first-line antidepressants among older adults using filled prescription sequences: A nationwide cohort study
Differences in the effectiveness of antidepressant medications according to age are uncertain. In a nationwide cohort from the French national health system, filled prescription sequences were used to compare the acceptability of 20 antidepressants by patient age. The primary outcome was clinical acceptability measured by the continuation/change ratio over the six-month period following introduction of the first-line treatment. 257,504 participants aged <65 and 83,673 aged ≥65 were included. Acceptability substantially differed between age groups.
Authors
- Antoine Rachas (ORCID: https://orcid.org/0000-0001-9226-9071)
- N. Hoertel
- F. Limosin
- Pierre Denis
- Mark Olfson
- Cédric Lemogne
- Carlos Blanco
- Charles Ouazana-Vedrines
- Philippe Tuppin
- Thomas Lesuffleur
Institutions
- Délégation Paris 5 (FR)
- National Institute on Drug Abuse (US)
- Inserm (FR)
- Université Paris Cité (FR)
- New York Psychoanalytic Society and Institute (US)
- Sorbonne Université (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Corentin-Celton (FR)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- l'Assurance Maladie (FR)
- Centre de Recherche Épidémiologie et Statistique (FR)
- Columbia University (US)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1016/j.jad.2026.121154
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00