Head-to-head comparison of [177Lu]Lu-FAP-2286 and [161Tb]Tb-FAP-2286 efficacy in a PDAC mouse model
In our in vitro and in vivo studies, [<sup>177</sup>Lu]Lu-FAP-2286 and [<sup>161</sup>Tb]Tb-FAP-2286 demonstrated similar behavior. In the applied PDAC mouse model, FAP-TRT showed limited therapeutic efficacy, most likely due to the limited radiopharmaceutical uptake observed in the tumors. This hampered determination of a potential benefit of either radioisotope for FAP-TRT. Of note, a modest response was observed in the tandem therapy group that first received [<sup>177</sup>Lu]Lu-FAP-2286, followed by [<sup>161</sup>Tb]Tb-FAP-2286.
Authors
- Circe D. van der Heide
- Carolline Ntihabose
- Simone U. Dalm (ORCID: https://orcid.org/0000-0002-6393-6901)
- Debra Stuurman (ORCID: https://orcid.org/0000-0003-4923-1312)
- Yann Seimbille
- Hanyue Ma
- Erik de Blois
- Michail C. Doukas
- Mark Konijnenberg
- Corrina de Ridder
Institutions
- Erasmus MC (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1186/s13550-026-01372-5
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00