03 02 Metastasis Base Architecture Lung Inflamatory Squamous Cell Carcinoma

Key findings include: (1) Site-specific metabolic signatures– lymph nodes exhibit glycolytic dominance with MCT4-mediated lactate export (2.73 mM/h); lung metastases show oxidative metabolism withROS elevation (3.2× primary) and pentose phosphate pathway upregulation (4.5×); liver displays extremelipid droplet accumulation (12.2× TAG storage) with NRF2 constitutive activation; bone demonstrates bimodal dormancy (β-oxidation 70% ATP) versus reactivation (glycolytic switch); brain maintains ultra-highoxidative phosphorylation (75% ATP) with glutamate-mediated neurotoxicity.