Advances in Theobromine Derivatives for Cancer Treatment: Synthesis Strategies and Biological Effects

A naturally occurring xanthine derivative, theobromine has garnered considerable attention due to its broad range of biological activities and potential medical applications. In recent decades, theobromine chemistry has garnered considerable attention due to its numerous biological applications. The present study reports on several methods for synthesizing theobromine derivatives and their anticancer activity. Numerous biological properties, including antioxidant, anti-tumor, anti-inflammatory, bronchodilator, cardiovascular, and antibacterial properties, are provided by theobromine and its derivatives, which are members of the nitrogen-containing heterocycle family. Our findings highlight the therapeutic potential of theobromine as an anticancer agent. In addition to compiling the literature on theobromine's anticancer activity as reported by researchers, this study aims to highlight the most recent advancements regarding theobromine and provide a comprehensive understanding of theobromine, thereby opening the door for future research and therapeutic improvements.