A vascularized three-dimensional model integrating primary breast tumor cells and microvascular fragments: mimicking the tumor microenvironment involved in chemoresistance
Collectively, these findings establish angiotumoroids as a robust and physiologically relevant in vitro model for studying tumor vascularization, ECM dynamics, and therapeutic response. This platform holds significant promise for predictive cancer research and preclinical drug screening, bridging the gap between traditional in vitro systems and in vivo models.
Authors
- Simone Dario Scilabra (ORCID: https://orcid.org/0000-0001-7300-6153)
- Monica Salamone (ORCID: https://orcid.org/0000-0002-2274-927X)
- Cinà Paolo
- Giulio Ghersi (ORCID: https://orcid.org/0000-0001-7250-9808)
- Simona Campora (ORCID: https://orcid.org/0000-0003-3786-6812)
- Gabriele Lo Buglio
- Margot Lo Pinto (ORCID: https://orcid.org/0009-0003-0394-9414)
- Francesco La Monica
- Federico Gangemi
Institutions
- University of Copenhagen (DK)
- Institute for Biomedical Research and Innovation (IT)
- Ri.MED (IT)
- National Research Council (IT)
- Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s12935-025-04154-6
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Università degli Studi di Palermo
- Fondazione Ri.Med