Memory B cell subset shapes antitumor immunity and response to PD-1 blockade in mismatch repair-deficient colorectal cancers
In conclusion, these findings show that CCL19 generated by STING/type I IFN/STAT1 pathway in dMMR/MSI-H CRC cells can promote the expansion of memory B cells, which suppresses tumor growth and enhances the efficacy of PD-1 blockade.
Authors
- Jiahao Jiang (ORCID: https://orcid.org/0009-0009-5712-5289)
- Yue Hu (ORCID: https://orcid.org/0000-0002-4567-4223)
- Lingzhi Wang (ORCID: https://orcid.org/0000-0001-5585-5426)
- He Huang (ORCID: https://orcid.org/0000-0002-2723-1621)
- Zhian Chen
- Xinhua Chen
- Yijie Xi
- Yihong Wan
- Xinyuan Mao
Institutions
- Shenzhen Bay Laboratory (CN)
- Nanfang Hospital (CN)
- Zhongshan People's Hospital (CN)
- Peking University Shenzhen Hospital (CN)
- Southern Medical University (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1136/jitc-2025-012121
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00