191Pt-labeled trithiol-Hoechst-PSMA: preliminary evaluation of conjugates designed for delivery to genomic DNA of PSMA-positive cancers
This study highlighted the importance of the linkers between the three components (trithiol-Hoechst-PSMA) and demonstrated binding of intravenously administered [<sup>191</sup>Pt]Pt-THP3-4 and [<sup>191</sup>Pt]Pt-THP3-8 to DNA in PSMA-positive tumors. Our compound designs and findings could be a useful foundation for DNA-targeted Auger electron cancer therapy, especially with Pt radionuclides.
Authors
- Yutian Feng (ORCID: https://orcid.org/0000-0003-3647-7292)
- Hitomi Sudo (ORCID: https://orcid.org/0000-0001-5012-6435)
- Honoka Obata (ORCID: https://orcid.org/0000-0002-8408-6416)
- Michael R. Zalutsky (ORCID: https://orcid.org/0000-0002-5456-0324)
- Katsuyuki Minegishi
- Yongxiang Zheng (ORCID: https://orcid.org/0000-0002-9068-5765)
- Chie Kajiwara
- Atsushi B. Tsuji
- Aya Sugyo
- Ming-Rong Zhang
Institutions
- Duke University (US)
- Theranostics (New Zealand) (NZ)
- National Institutes for Quantum Science and Technology (JP)
- Duke Medical Center (US)
- Duke University Hospital (US)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1186/s41181-025-00420-0
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00