Overweight worsens the metabolic presentation of type 1 diabetes mellitus in children

Children with overweight presented with more severe metabolic derangement at T1DM onset. Obese and overweight children have a higher risk of having DKA at presentation despite elevated C-peptide levels, which suggest a greater residual β-cell function. These findings support the hypothesis that other factors, such as chronic inflammation, may contribute to T1DM manifestation. Our findings highlight the impact of overweight and obesity on the clinical presentation of T1DM. In case of weight loss in obese and overweight children, more attention should be paid to the classical symptoms of T1DM.