How tobacco use disorder affects gray matter aberrance: The mediating effect of glymphatic system function
The current study revealed abnormalities of DTI-ALPS index in TUD and identified that abnormal GS function in TUD individuals could be the potential mechanism underlying the effects of tobacco exposure on GMV changes. These findings provided further evidence for understanding the pathogenesis of TUD and suggested GS function could serve as a new target for clinical therapeutic strategies.
Authors
- Mengzhe Zhang (ORCID: https://orcid.org/0000-0003-0682-1574)
- Bohui Mei
- Yunfei Wang (ORCID: https://orcid.org/0000-0003-3030-1851)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-7089-1254)
- Kaixin Li (ORCID: https://orcid.org/0000-0003-4496-5448)
- Longyao Ma (ORCID: https://orcid.org/0009-0008-7933-9168)
- Mengzhu Wang
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
- Siemens (China) (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.brainresbull.2026.111725
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00