Genetic correlations among diaphragmatic, femoral, inguinal, ventral, and umbilical hernias and identification of their candidate genes

This study reveals a shared genetic basis among common hernia subtypes and identifies three shared candidate genes (BMP6, MYCBPAP, and ZNF75A). Elevated BMP6 protein levels were associated with a reduced risk of multiple hernia types. These findings provide new insights into the genetic correlations and potential pathogenic mechanisms underlying hernia. Future functional studies are needed to elucidate the roles of these genes in abdominal wall tissue.