Stage IVB ovarian carcinosarcoma in BRCA wild-type patients: two case reports of unexpected long-term remission
These two reports challenge the long-held perception of uniformly poor outcomes in metastatic ovarian carcinosarcoma. Complete cytoreductive surgery combined with tailored systemic and maintenance therapies can achieve sustained remission even in advanced-stage BRCA-wild-type patients. Broader molecular profiling and international collaboration are essential to refine management strategies for this rare and aggressive malignancy.
Authors
- Davide Massa (ORCID: https://orcid.org/0000-0002-1390-4055)
- Giulia Spagnol
- O. De Tommasi
- Angela Guerriero (ORCID: https://orcid.org/0000-0001-9981-7448)
- Margherita Nardin
- Sofia Bigardi
- Roberto Tozzi
- Carlo Saccardi
- Giulia Tasca
- Marco Noventa
Institutions
- University of Padua (IT)
- Istituto Oncologico Veneto (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fonc.2025.1728398
- Primary Topic
- Uterine Myomas and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00