Stage IVB ovarian carcinosarcoma in BRCA wild-type patients: two case reports of unexpected long-term remission

These two reports challenge the long-held perception of uniformly poor outcomes in metastatic ovarian carcinosarcoma. Complete cytoreductive surgery combined with tailored systemic and maintenance therapies can achieve sustained remission even in advanced-stage BRCA-wild-type patients. Broader molecular profiling and international collaboration are essential to refine management strategies for this rare and aggressive malignancy.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-09
DOI
https://doi.org/10.3389/fonc.2025.1728398
Primary Topic
Uterine Myomas and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Stage IVB ovarian carcinosarcoma in BRCA wild-type patients: two case reports of unexpected long-term remission

Davide Massa, Giulia Spagnol, O. De Tommasi, Angela Guerriero et al.
Frontiers in Oncology
Uterine Myomas and Treatments
article

Stage IVB ovarian carcinosarcoma in BRCA wild-type patients: two case reports of unexpected long-term remission

Davide Massa, Giulia Spagnol, O. De Tommasi, Angela Guerriero, Margherita Nardin, Sofia Bigardi, Roberto Tozzi, Carlo Saccardi, Giulia Tasca, Marco Noventa
article en

Abstract

These two reports challenge the long-held perception of uniformly poor outcomes in metastatic ovarian carcinosarcoma. Complete cytoreductive surgery combined with tailored systemic and maintenance therapies can achieve sustained remission even in advanced-stage BRCA-wild-type patients. Broader molecular profiling and international collaboration are essential to refine management strategies for this rare and aggressive malignancy.

Frontiers in OncologyVol. 15
University of Padua (IT), Istituto Oncologico Veneto (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Gender equality
Openalex Percentile: Top 94%
Uterine Myomas and Treatments
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