The Hepatic Transcriptomes of Two Mouse Models of Liver Fibrosis Reveal Shared Molecular Patterns Associated with a Common Dysregulation of Folate Metabolism
We identify a common dysregulation in folate metabolism in two widely used rodent models of liver fibrosis and highlight the consequent metabolic disturbances. Analysis of hepatic transcriptional profiles of MCD and GNMTKO mice reveals novel association of the transcriptional regulators STAT5b, AhR, and ARNT with liver fibrosis.
Authors
- Robin Paul da Silva
- Brandon J. Eudy
Institutions
- University of Florida (US)
- University of Manitoba (CA)
Publication Details
- Journal
- Journal of Nutrition
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1016/j.tjnut.2025.101349
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00