Fructose-sweetened beverages induce diurnal redox dysregulation in pediatric MASLD
Our findings demonstrate that plasma redox states vary diurnally in children and are more oxidized in those with MASLD. Fructose intake increased oxidation of the GSH/GSSG redox couple and lowered GSH concentrations overnight, indicating heightened oxidative stress. These results identify fructose as a driver of redox imbalance in pediatric MASLD and support fructose reduction and glutathione restoration as therapeutic targets.
Authors
- Zachery Jarrell (ORCID: https://orcid.org/0000-0003-4670-1497)
- Dean P. Jones (ORCID: https://orcid.org/0000-0002-2090-0677)
- Shasha Bai (ORCID: https://orcid.org/0000-0003-4999-327X)
- Helaina Huneault (ORCID: https://orcid.org/0000-0003-3866-2387)
- Jean A. Welsh (ORCID: https://orcid.org/0000-0002-1372-5524)
- M. Vos
- Ana Ramirez Tovar (ORCID: https://orcid.org/0000-0002-9038-6589)
- Kelsey Chatman
- Scott Gillespie
- Cristian Sanchez-Torres
- Lucia A. Gonzalez-Ramirez
- Thomas R. Ziegler
Institutions
- Emory University (US)
- Emory University Hospital (US)
- Helen DeVos Children's Hospital (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Redox Biology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.redox.2026.104012
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00